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CBQB Symposium - Feb 2024

At least once a semester (but hopefully more) we will meet to discuss different example of how  biological dynamics and interactions across scales lead to  multi cellular co-operation and behavior. Focusing specifically on the computatonal and experimental methods used to reach our understanding.  Every mini symposium will include two interesting lectures and a break for discussion over lunch or snacks. 

Next symposium: Wednesday 14.02- @Observatory (מצפור) 30th floor, Eshkol Building, University of Haifa.

From molecular interactions to cellular interactions - multi-scale networks of inter and intra cell signaling and their control of adaptation and development

Speaker

Question and Topic

Background materials

11:00 am – Yaron E. Antebi, Department of Molecular Genetics Weizmann Institute of Science.

How do cells encode combinatorial information from their signaling environment to control the process of cell fate determination? Deciphering the cellular integration of contradictory BMP and TGFβ signals

  1. Antebi, Y.E., Linton, J.M., et al., Combinatorial Signal Perception in the BMP Pathway Cell 2017;170(6): 1184-96.
  2. Klumpe, H.E., Garcia-Ojalvo, J., Elowitz, M.B., and Antebi, Y.E., The Computational Capabilities of Many to Many Protein Interaction Networks Cell Systems 2023; 14(6):430-46.

between lectures, from noon to 1pm,  we will have a discussion and lunch – details TBA

01:00 pm – Smadar Ben-Tabou de-Leon, Department of Marine Biology, University of Haifa

How do cells build organs? On the interplay between genetic and mechanical information processing during sea urchin skeletogenesis

  1. Wolfenson H, Yang B, Sheetz MP. Steps in Mechanotransduction Pathways that Control Cell Morphology. Annu Rev Physiol. 2019;81:585-605.
  2. Ben-Tabou de-Leon S. The Evolution of Biomineralization through the Co-Option of Organic Scaffold Forming Networks. Cells. 2022;11(4).